Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of (R)-Mexiletine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A known ✓ | P35499 | 12/20 | 1.00 |
| ▸ | SCN5A known ✓ | Q14524 | 3/20 | 1.00 |
| ▸ | SCN1A known ✓ | P35498 | 2/20 | 1.00 |
| ▸ | SCN9A known ✓ | Q15858 | 2/20 | 1.00 |
| ▸ | SCN7A known ✓ | Q01118 | 1/20 | 1.00 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 1.00 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 1.00 |
| ▸ | SCN11A known ✓ | Q9UI33 | 1/20 | 1.00 |
| ▸ | SCN8A known ✓ | Q9UQD0 | 1/20 | 1.00 |
| ▸ | SCN10A known ✓ | Q9Y5Y9 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | MAOA | P21397 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | KCNK3 | O14649 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mexiletine SCHEMBL8858385 | 1.00 | SCN4A (1.00) | SCN4ASCN5ALMNACYP2D6SCN1A | |
| (S)-Mexiletine SCHEMBL13046569 | 1.00 | SCN4A (1.00) | SCN4ASCN5ALMNACYP2D6SCN1A | |
| Mexiletine SCHEMBL16081 | 1.00 | SCN4A (1.00) | SCN4ASCN5ALMNACYP2D6SCN1A | |
| Mexiletine SCHEMBL6521444 | 0.98 | SCN5A (1.00) | SCN4ASCN5ALMNACYP2D6SCN1A | |
| (R)-Mexiletine SCHEMBL29366590 | 0.98 | SCN5A (1.00) | SCN4ASCN5ALMNACYP2D6SCN1A | |
| Mexiletine SCHEMBL6665250 | 0.98 | SCN5A (1.00) | SCN4ASCN5ALMNACYP2D6SCN1A | |
| (S)-Mexiletine SCHEMBL3645798 | 0.98 | SCN5A (1.00) | SCN4ASCN5ALMNACYP2D6SCN1A | |
| Mexiletine SCHEMBL42226 | 0.98 | SCN5A (1.00) | SCN4ASCN5ALMNACYP2D6SCN1A | |
| Mexiletine SCHEMBL1652207 | 0.96 | SCN4A (0.92) | SCN4ASCN5ALMNACYP2D6SCN1A | |
| Mexiletine SCHEMBL8819167 | 0.89 | SCN4A (0.80) | SCN4ASCN5ALMNACYP2D6SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 17333 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| US-20260097012-A1 | COMPOSITIONS AND METHODS FOR TREATING GRAFT-RELATED ARRHYTHMIA | BLUEROCK THERAPEUTICS LP (US) | 2026-04-09 | — | — | US | claimed |
| US-12565653-B2 | ATAXIN3 (ATXN3) RNAi agent compositions and methods of use thereof | ALNYLAM PHARMACEUTICALS, INC. (US) | 2026-03-03 | — | — | US | claimed |
| EP-4683627-A1 | AMELIORATION OF DRUG-DRUG INTERACTIONS | Ontrack Therapeutics Limited (GB) | 2026-01-28 | — | — | EP | claimed |
| EP-4680201-A1 | COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS | Streck LLC (US) | 2026-01-21 | — | — | EP | claimed |
| US-12528794-B2 | MAO-B inhibitor DRG-MAOB-1 for use in treatment of neurodegenerative diseases | BAHCESEHIR UNIVERSITESI (TR) | 2026-01-20 | — | — | US | claimed |
| WO-2025230475-A1 | BETA-SILYL ALKYNOATES: VERSATILE REAGENTS FOR BIOCOMPATIBLE AND SELECTIVE AMIDE BOND FORMATION | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2025-11-06 | — | — | WO | claimed |
| EP-4593821-A2 | COMPOSITIONS AND METHODS FOR TREATING GRAFT-RELATED ARRHYTHMIA | Bluerock Therapeutics LP (US) | 2025-08-06 | — | — | EP | claimed |
| EP-4587119-A1 | METHODS OF TREATMENT WITH AN IBOGA ALKALOID | The Board of Trustees of the Leland Stanford Junior University (US) | 2025-07-23 | — | — | EP | claimed |
| EP-4587019-A2 | COMPOSITIONS OF IBOGA ALKALOIDS AND METHODS OF TREATMENT | The Board of Trustees of the Leland Stanford Junior University (US) | 2025-07-23 | — | — | EP | claimed |
| WO-1997037629-A1 | PROCESS FOR ENCAPSULATION OF CAPLETS IN A CAPSULE AND SOLID DOSAGE FORMS OBTAINABLE BY SUCH PROCESS | WARNER-LAMBERT COMPANY (US) | 1997-10-16 | — | — | WO | claimed |
| US-5585243-A | SEPARATELY INCUBATING HUMAN PLATELETS WITH BLOOD SAMPLE ANDREAGENT DRUG SOLUTION TO FORM COMPLEXES, DETERMINING AMOUNT OF BOUND ANTIBODY | THE BLOOD CENTER OF SOUTHEASTERN WISCONSIN, INC. (US) | 1996-12-17 | — | — | US | claimed |
| US-5585380-A | ADMINISTERING XANTHINE DERIVATIVE | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1996-12-17 | — | — | US | claimed |
| EP-0659082-A1 | USE OF CYTOCHROME P450 INHIBITORS FOR INHIBITING THE METABOLISM OF NITROGEN SUBSTITUTED ACRIDINE | WARNER-LAMBERT COMPANY (US) | 1995-06-28 | — | — | EP | claimed |
| WO-1995008116-A1 | METHOD OF DETECTING CYTOPENIA THAT IS MEDIATED BY DRUG-DEPENDENT ANTIBODY BINDING TO BLOOD CELLS | THE BLOOD CENTER OF SOUTHEASTERN WISCONSIN, INC. (US) | 1995-03-23 | — | — | WO | claimed |
| WO-1994005296-A2 | USE OF CYTOCHROME P450 INHIBITORS FOR INHIBITING THE METABOLISM OF NITROGEN SUBSTITUTED ACRIDINE | WARNER-LAMBERT COMPANY (US) | 1994-03-17 | — | — | WO | claimed |
| EP-0406289-A1 | PREPARATION FOR PROMOTING AND STIMULATING HAIR GROWTH | BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) | 1991-01-09 | — | — | EP | claimed |
| WO-1989009046-A1 | PREPARATION FOR PROMOTING AND STIMULATING HAIR GROWTH | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 1989-10-05 | — | — | WO | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| US-4459279-A | MEXILETINE, WATER INSOLUBLE FILM FORMER, SUSTAINED RELEASE | BOEHRINGER INGELHEIM GMBH (DE) | 1984-07-10 | — | — | US | claimed |