Mexiletine

Mexiletine

SCHEMBL42226

Cc1cccc(C)c1OCC(C)N.Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A

The experimentally established mechanism targets of Mexiletine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN5A known ✓ Q14524 3/20 1.00
SCN1A known ✓ P35498 2/20 1.00
SCN9A known ✓ Q15858 2/20 1.00
SCN4A known ✓ P35499 10/20 0.96
SCN7A known ✓ Q01118 1/20 0.96
SCN2A known ✓ Q99250 1/20 0.96
SCN3A known ✓ Q9NY46 1/20 0.96
SCN11A known ✓ Q9UI33 1/20 0.96
SCN8A known ✓ Q9UQD0 1/20 0.96
SCN10A known ✓ Q9Y5Y9 1/20 0.96
LMNA P02545 3/20 1.00
CYP2D6 P10635 3/20 0.96
CYP1A2 P05177 2/20 0.96
CYP3A4 P08684 2/20 0.96
NFKB1 P19838 2/20 0.96
TSHR P16473 2/20 0.96
MAOA P21397 2/20 0.96
CYP2C9 P11712 1/20 0.96
KCNK3 O14649 1/20 0.96
CACNA1F O60840 1/20 0.96

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mexiletine SCHEMBL6521444 1.00 SCN5A (1.00) SCN5ALMNASCN1ASCN9ASCN4A
(S)-Mexiletine SCHEMBL3645798 1.00 SCN5A (1.00) SCN5ALMNASCN1ASCN9ASCN4A
Mexiletine SCHEMBL6665250 1.00 SCN5A (1.00) SCN5ALMNASCN1ASCN9ASCN4A
(R)-Mexiletine SCHEMBL29366590 1.00 SCN5A (1.00) SCN5ALMNASCN1ASCN9ASCN4A
(S)-Mexiletine SCHEMBL13046569 0.98 SCN4A (1.00) SCN5ALMNASCN1ASCN9ASCN4A
(R)-Mexiletine SCHEMBL16082 0.98 SCN4A (1.00) SCN5ALMNASCN1ASCN9ASCN4A
Mexiletine SCHEMBL8858385 0.98 SCN4A (1.00) SCN5ALMNASCN1ASCN9ASCN4A
Mexiletine SCHEMBL16081 0.98 SCN4A (1.00) SCN5ALMNASCN1ASCN9ASCN4A
Mexiletine SCHEMBL1652207 0.94 SCN4A (0.92) SCN5ALMNASCN1ASCN9ASCN4A
Mexiletine SCHEMBL8819167 0.88 SCN4A (0.80) SCN5ALMNASCN1ASCN9ASCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4190 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121585847-A Screen projection processing method, device and storage medium 长城汽车股份有限公司 2026-02-27 CN claimed
EP-4680201-A1 COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS Streck LLC (US) 2026-01-21 EP claimed
CN-119379366-B Insurance advertisement dynamic loading method based on Internet 星火智云(上海)科技发展有限公司 2025-06-13 CN claimed
CN-120020942-A Audio generation method, system, device and storage medium 北京字跳网络技术有限公司 2025-05-20 CN claimed
CN-119967204-A Video and audio digital copyright encryption method, decryption method, system and device 央视国际网络有限公司 2025-05-09 CN claimed
US-20250120930-A1 COMPOSITIONS CONTAINING DOFETILIDE AND MEXILETINE AND USES THEREOF FB-HRS, LLC 2025-04-17 US claimed
CN-119759586-A Resource allocation method based on event response 众合云科信息技术集团有限公司 2025-04-04 CN claimed
CN-119728658-A Audio broadcasting method, device, system, electronic equipment and storage medium 科大讯飞股份有限公司 2025-03-28 CN claimed
CN-119417661-A Multimedia interaction method and system 山东悦正达信用服务有限公司 2025-02-11 CN claimed
WO-2024192232-A9 COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS STRECK LLC (US) 2025-02-06 WO claimed
WO-1992013935-A1 PHOSPHATE-FREE CLEANING AGENT HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1992-08-20 WO claimed
EP-0425428-A2 Method for preparation of sodium silicates HOECHST AKTIENGESELLSCHAFT (DE) 1991-05-02 EP claimed
EP-0387251-A1 USE OF FILLERS COATED WITH TRIALKOXYSILANES NAINTSCH MINERALWERKE GESELLSCHAFT M.B.H. (AT) 1990-09-19 EP claimed
EP-0293640-A2 Process for the production of crystalline sodium silicates having a layer structure HOECHST AKTIENGESELLSCHAFT (DE) 1988-12-07 EP claimed
EP-0126795-B1 METHOD FOR MANUFACTURING WELDED PIPES KAWASAKI JUKOGYO KABUSHIKI KAISHA (JP) 1988-06-01 EP claimed
EP-0082254-B1 IMAGE FORMING APPARATUS KABUSHIKI KAISHA TOSHIBA (JP) 1986-03-12 EP claimed
EP-0034183-B1 TYING UP MACHINE Maschinenfabrik Gerd Mosca GmbH (DE) 1983-05-11 EP claimed
EP-0054241-A1 Connection of a mast foot to a sail-board Marker, Hannes (DE) 1982-06-23 EP claimed
EP-0034183-A1 TYING UP MACHINE. MOSCA G MASCHF (DE) 1981-08-26 EP claimed
WO-1981000548-A1 TYING UP MACHINE MOSCA G MASCHF (DE) 1981-03-05 WO claimed