Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.45 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16993349 | 0.92 | GPR119 (0.49) | GPR119HPGD | |
| SCHEMBL34473801 | 0.90 | USP30 (0.50) | USP30GPR119NR1D1HSD11B1NR1H2 | |
| SCHEMBL19918238 | 0.90 | USP30 (0.50) | USP30GPR119NR1D1HSD11B1NR1H2 | |
| SCHEMBL19720085 | 0.85 | USP30 (0.46) | USP30GPR119NR1D1HSD11B1JAK2 | |
| SCHEMBL34473959 | 0.84 | USP30 (0.50) | USP30GPR119NR1D1HSD11B1NR1H2 | |
| SCHEMBL31075718 | 0.83 | USP30 (0.41) | USP30GPR119NR1D1HSD11B1JAK2 | |
| SCHEMBL15410506 | 0.82 | GPR119 (0.52) | GPR119HPGD | |
| SCHEMBL23555641 | 0.81 | JAK2 (0.60) | USP30GPR119NR1D1HSD11B1JAK2 | |
| SCHEMBL18429026 | 0.81 | GPR119 (0.51) | GPR119HPGD | |
| SCHEMBL20906990 | 0.81 | USP30 (0.52) | USP30GPR119HSD11B1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145512-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-18 | — | — | WO | disclosed |