Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.75 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.75 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.75 |
| ▸ | TNF | P01375 | 9/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17471691 | 0.89 | RIPK1 (0.59) | RIPK1RIPK2RIPK3TNFL3MBTL1 | |
| SCHEMBL16084957 | 0.87 | RIPK1 (0.61) | RIPK1RIPK2RIPK3TNFL3MBTL1 | |
| SCHEMBL17471690 | 0.86 | RIPK1 (0.99) | RIPK1RIPK2RIPK3TNFL3MBTL1 | |
| SCHEMBL29686895 | 0.85 | RIPK1 (1.00) | RIPK1RIPK2RIPK3TNFL3MBTL1 | |
| SCHEMBL29353518 | 0.85 | RIPK1 (1.00) | RIPK1RIPK2RIPK3TNFL3MBTL1 | |
| SCHEMBL21678896 | 0.85 | RIPK1 (1.00) | RIPK1RIPK2RIPK3TNFL3MBTL1 | |
| SCHEMBL16084942 | 0.85 | RIPK1 (1.00) | RIPK1RIPK2RIPK3TNFL3MBTL1 | |
| SCHEMBL16084951 | 0.85 | RIPK1 (0.59) | RIPK1RIPK2RIPK3TNFL3MBTL1 | |
| SCHEMBL17471719 | 0.85 | RIPK1 (0.99) | RIPK1RIPK2RIPK3TNFL3MBTL1 | |
| SCHEMBL16084944 | 0.84 | RIPK1 (0.90) | RIPK1RIPK2RIPK3TNFL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145022-A1 | HYBRID NECROPTOSIS INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-18 | — | — | WO | disclosed |