Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.52 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 14/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | ROR1 | Q01973 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | ABL2 | P42684 | 2/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17471706 | 0.90 | RIPK1 (0.52) | RIPK1RIPK2RIPK3ABL1CSF1R | |
| SCHEMBL17471701 | 0.90 | RIPK1 (0.52) | RIPK1RIPK2RIPK3ABL1CSF1R | |
| SCHEMBL17471724 | 0.89 | RIPK1 (0.52) | RIPK1RIPK2RIPK3ABL1CSF1R | |
| SCHEMBL17471732 | 0.81 | ABL1 (0.46) | RIPK1RIPK2RIPK3ABL1CSF1R | |
| SCHEMBL17471734 | 0.81 | ABL1 (0.46) | RIPK1RIPK2RIPK3ABL1CSF1R | |
| SCHEMBL14705592 | 0.80 | CSF1R (0.55) | ABL1CSF1RROR1CYP3A4KCNH2 | |
| SCHEMBL17471717 | 0.78 | CSF1R (0.57) | ABL1CSF1RROR1CYP3A4KCNH2 | |
| SCHEMBL17471729 | 0.76 | CSF1R (0.56) | RIPK1RIPK2RIPK3ABL1CSF1R | |
| SCHEMBL22243490 | 0.75 | CSF1R (0.66) | ABL1CSF1RROR1CYP3A4KCNH2 | |
| SCHEMBL15096062 | 0.74 | ROR1 (0.67) | RIPK1RIPK2RIPK3ABL1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145022-A1 | HYBRID NECROPTOSIS INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-18 | — | — | WO | disclosed |