Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485108 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAPOLBMEN1KMT2A | |
| SCHEMBL14485232 | 0.85 | MAPT (0.82) | SMN1; SMN2LMNAPOLBMEN1KMT2A | |
| SCHEMBL15838893 | 0.84 | LMNA (0.73) | SMN1; SMN2LMNAPOLBMEN1KMT2A | |
| SCHEMBL15952977 | 0.84 | SIRT2 (0.90) | SMN1; SMN2LMNAPOLBSIRT2 | |
| SCHEMBL15838850 | 0.82 | LMNA (0.69) | SMN1; SMN2LMNAPOLBMEN1KMT2A | |
| SCHEMBL15838777 | 0.82 | SIRT2 (0.78) | SMN1; SMN2LMNAPOLBMEN1KMT2A | |
| SCHEMBL15953983 | 0.81 | SIRT2 (0.86) | SMN1; SMN2LMNAPOLBSIRT2 | |
| SCHEMBL15838811 | 0.81 | SIRT2 (0.83) | SMN1; SMN2LMNAPOLBSIRT2 | |
| SCHEMBL13532179 | 0.80 | LMNA (1.00) | SMN1; SMN2LMNAPOLBMEN1KMT2A | |
| SCHEMBL15953200 | 0.80 | SIRT2 (1.00) | SMN1; SMN2LMNAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145642-A9 | NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-11-13 | — | — | WO | disclosed |
| WO-2014145642-A2 | NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-09-18 | — | — | WO | disclosed |