SCHEMBL16085431

SCHEMBL16085431

COc1ccccc1C(=O)N1CCc2cc(-c3nc(NC(=O)Cc4ccc5c(c4)OCO5)sc3C)ccc21

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 8/20 0.84
POLB P06746 2/20 0.84
MAFG O15525 1/20 0.84
HPGD P15428 1/20 0.84
NFE2L2 Q16236 1/20 0.84
L3MBTL1 Q9Y468 1/20 0.84
LMNA P02545 6/20 0.82
HTT P42858 4/20 0.82
ALDH1A1 P00352 5/20 0.75
MAPT P10636 2/20 0.53
GAA P10253 1/20 0.53
NT5E P21589 1/20 0.53
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
USP2 O75604 1/20 0.46
CFTR P13569 3/20 0.45
ROCK2 O75116 1/20 0.45
NPSR1 Q6W5P4 1/20 0.44
SLC12A2 P55011 1/20 0.44
WNK1 Q9H4A3 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16085433 0.92 SMN1; SMN2 (0.81) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL29419037 0.92 SMN1; SMN2 (1.00) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085609 0.92 SMN1; SMN2 (1.00) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL30440736 0.92 SMN1; SMN2 (1.00) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085439 0.91 SMN1; SMN2 (0.88) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085434 0.90 SMN1; SMN2 (0.87) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085453 0.90 SMN1; SMN2 (1.00) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085466 0.90 SMN1; SMN2 (0.85) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085413 0.89 SMN1; SMN2 (0.86) SMN1; SMN2POLBMAFGHPGDNFE2L2
SCHEMBL16085432 0.88 SMN1; SMN2 (0.83) SMN1; SMN2POLBMAFGHPGDNFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014145642-A9 NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY THE JOHNS HOPKINS UNIVERSITY (US) 2014-11-13 WO disclosed
WO-2014145642-A2 NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY THE JOHNS HOPKINS UNIVERSITY (US) 2014-09-18 WO disclosed