Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.81 |
| ▸ | LMNA | P02545 | 5/20 | 0.81 |
| ▸ | HTT | P42858 | 3/20 | 0.81 |
| ▸ | POLB | P06746 | 2/20 | 0.80 |
| ▸ | MAFG | O15525 | 1/20 | 0.80 |
| ▸ | HPGD | P15428 | 1/20 | 0.80 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.42 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16085431 | 0.92 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNAHTTPOLBMAFG | |
| SCHEMBL16085432 | 0.90 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAHTTPOLBMAFG | |
| SCHEMBL16085453 | 0.89 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAHTTPOLBMAFG | |
| SCHEMBL29419037 | 0.89 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAHTTPOLBMAFG | |
| SCHEMBL30440736 | 0.89 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAHTTPOLBMAFG | |
| SCHEMBL16085609 | 0.89 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAHTTPOLBMAFG | |
| SCHEMBL16085439 | 0.89 | SMN1; SMN2 (0.88) | SMN1; SMN2LMNAHTTPOLBMAFG | |
| SCHEMBL16085434 | 0.88 | SMN1; SMN2 (0.87) | SMN1; SMN2LMNAHTTPOLBMAFG | |
| SCHEMBL16085466 | 0.87 | SMN1; SMN2 (0.85) | SMN1; SMN2LMNAHTTPOLBMAFG | |
| SCHEMBL16085413 | 0.86 | SMN1; SMN2 (0.86) | SMN1; SMN2LMNAHTTPOLBMAFG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145642-A9 | NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-11-13 | — | — | WO | disclosed |
| WO-2014145642-A2 | NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-09-18 | — | — | WO | disclosed |