Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mifepristone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 10/20 | 1.00 |
| ▸ | PGR known ✓ | P06401 | 10/20 | 1.00 |
| ▸ | AR | P10275 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mifepristone SCHEMBL19236544 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 | |
| Mifepristone SCHEMBL13110930 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 | |
| Mifepristone SCHEMBL19100510 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 | |
| Mifepristone SCHEMBL13840946 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 | |
| Mifepristone SCHEMBL10622661 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 | |
| Mifepristone SCHEMBL10625406 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 | |
| Mifepristone SCHEMBL10607607 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 | |
| Mifepristone SCHEMBL918725 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 | |
| Mifepristone SCHEMBL20769786 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 | |
| Mifepristone SCHEMBL14870641 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 32868 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747611-A1 | OPTICAL ELECTRODE ANALYTE DETECTION SYSTEM AND METHODS OF USE | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| US-12629363-B2 | Prophylaxis and treatment of angioedema | PHARVARIS GMBH (CH) | 2026-05-19 | — | — | US | claimed |
| US-20260130899-A1 | METHOD OF TREATMENT FOR PREVENTION OF GLUCOCORTICOID TOXICITY AND/OR ENHANCEMENT OF MUSCLE REGENERATION VIA NEUTROPHIL ELASTASE INHIBITION | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2026-05-14 | — | — | US | claimed |
| US-12625150-B2 | Treatment of, and differential diagnosis between, ACTH-dependent Cushing's syndrome and ACTH-independent Cushing's syndrome | CORCEPT THERAPEUTICS INCORPORATED (US) | 2026-05-12 | — | — | US | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| US-12616781-B2 | Tubular nonwoven structure as active agent carrier for the atraumatic treatment of hollow organs, and a process for producing the same | BVS—Best Vascular Solutions GmbH (DE) | 2026-05-05 | — | — | US | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| US-20260115203-A1 | LOW-DOSE MIFEPRISTONE FOR THE TREATMENT OF ENDOMETRIOSIS ASSOCIATED PAIN | LABORATORIOS LITAPHAR S L (ES) | 2026-04-30 | — | — | US | claimed |
| US-20260115317-A1 | GENE THERAPY | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2026-04-30 | — | — | US | claimed |
| EP-0266303-B1 | ANTIGESTAGENS FOR THE INHIBITION OF UTERINE PROSTAGLANDIN SYNTHESIS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-07-29 | — | — | EP | claimed |
| EP-0446124-A2 | Use of antiprogestomimetics to synchronise parturition in livestock | ROUSSEL UCLAF (FR) | 1991-09-11 | — | — | EP | claimed |
| EP-0184471-B1 | PRODUCT CONTAINING AN ANTIPROGESTOMIMETIC AND A UTEROTONIC SUBSTANCE | ROUSSEL-UCLAF (FR) | 1990-11-14 | — | — | EP | claimed |
| US-4891368-A | ESTRANE AND GONANE STEROIDS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-02 | — | — | US | claimed |
| US-4888331-A | SIDE EFFECT REDUCTION; | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-12-19 | — | — | US | claimed |
| EP-0135400-B1 | ESTRADIENE DERIVATIVES LABELLED WITH TRITIUM, THEIR PREPARATION AND INTERMEDIATES FOR THEIR PREPARATION, AND THEIR UTILIZATION IN THE STUDY AND IN THE DETERMINATION OF STEROIDS IN BIOLOGICAL FLUIDS | ROUSSEL-UCLAF (FR) | 1988-06-01 | — | — | EP | claimed |
| EP-0139608-B1 | PROSTAGLANDINS AND ANTIGESTAGENS FOR THE ONSET OF LABOUR OR FOR THE INTERRUPTION OF PREGNANCY | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-06-01 | — | — | EP | claimed |
| EP-0135400-A2 | Estradiene derivatives labelled with tritium, their preparation and intermediates for their preparation, and their utilization in the study and in the determination of steroids in biological fluids | ROUSSEL-UCLAF (FR) | 1985-03-27 | — | — | EP | claimed |
| EP-0057115-B1 | STEROID DERIVATIVES SUBSTITUTED IN THE 11-BETA POSITION, PROCESS FOR THEIR PREPARATION, THEIR UTILIZATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1985-03-20 | — | — | EP | claimed |
| EP-0131491-A1 | Estradiene derivatives labelled with iodine, process for their preparation and intermediates in their preparation, and their use in the study and the radioimmunological determination of steroids in body fluids | ROUSSEL-UCLAF (FR) | 1985-01-16 | — | — | EP | claimed |