Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526496 | 0.82 | SMARCA2 (0.46) | SMN1; SMN2NPC1RAB9ACASP1LMNA | |
| SCHEMBL2646929 | 0.80 | CASP1 (0.41) | MAPTSMN1; SMN2NPC1RAB9AGFER | |
| SCHEMBL30453161 | 0.80 | CASP1 (0.41) | MAPTSMN1; SMN2NPC1RAB9AGFER | |
| SCHEMBL1038525 | 0.79 | CASP1 (0.48) | NPC1RAB9ACASP1 | |
| SCHEMBL19440997 | 0.77 | CASP1 (0.40) | MAPTSMN1; SMN2NPC1RAB9AGFER | |
| SCHEMBL19813305 | 0.77 | CYP2A6 (0.44) | MAPTIMPDH2ALDH1A1 | |
| SCHEMBL28685605 | 0.75 | CASP1 (0.48) | MAPTSMN1; SMN2NPC1RAB9ACASP1 | |
| SCHEMBL1754688 | 0.74 | MAPK1 (0.53) | MAPTNPC1RAB9ACASP1ATAD2 | |
| SCHEMBL16061219 | 0.73 | MAPK14 (0.60) | MAPTSMN1; SMN2NPC1RAB9AGFER | |
| SCHEMBL16092109 | 0.73 | CASP1 (0.43) | MAPTSMN1; SMN2NPC1RAB9AGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145485-A2 | MAP KINASE MODULATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-09-18 | — | — | WO | disclosed |