Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 3/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17547869 | 0.92 | TLR8 (0.47) | TLR9TLR8TLR7CYP11B2CYP11B1 | |
| SCHEMBL16092552 | 0.85 | BRD4 (0.37) | CYP11B2 | |
| SCHEMBL16092493 | 0.82 | KDM5B (0.48) | PLAT | |
| SCHEMBL16092522 | 0.82 | MEN1 (0.40) | TLR9TLR8TLR7CYP11B2CYP11B1 | |
| SCHEMBL16092280 | 0.81 | TTK (0.41) | CSNK2A1 | |
| SCHEMBL16092448 | 0.81 | KDM5B (0.46) | FASNPLAT | |
| SCHEMBL16092243 | 0.80 | KDM5A (0.43) | — | |
| SCHEMBL16092293 | 0.80 | KDM5A (0.39) | CYP11B2CYP11B1FASNPLAT | |
| SCHEMBL16092534 | 0.80 | EGLN1 (0.43) | — | |
| SCHEMBL16092255 | 0.80 | KDM5B (0.42) | PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015135094-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2015-09-17 | — | — | WO | disclosed |
| WO-2014139326-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |