Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | RECQL | P46063 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845977 | 1.00 | SMN1; SMN2 (0.79) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 | |
| SCHEMBL4068438 | 1.00 | SMN1; SMN2 (0.79) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 | |
| SCHEMBL4066993 | 0.98 | SMN1; SMN2 (0.81) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 | |
| SCHEMBL12418058 | 0.95 | SMN1; SMN2 (0.71) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 | |
| SCHEMBL5452364 | 0.95 | SMN1; SMN2 (0.75) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 | |
| SCHEMBL11253764 | 0.91 | SMN1; SMN2 (0.65) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 | |
| SCHEMBL4071039 | 0.91 | SMN1; SMN2 (0.68) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 | |
| Toluene SCHEMBL27696348 | 0.88 | ALDH1A1 (0.73) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 | |
| SCHEMBL23093579 | 0.83 | KDM4E (0.58) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 | |
| SCHEMBL6191704 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4ERECQLALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841282-B2 | Pyrrolidinone benzenesulfonamide derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-23 | — | — | US | disclosed |