Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | TTR | P02766 | 2/20 | 0.68 |
| ▸ | APP | P05067 | 2/20 | 0.68 |
| ▸ | MMP1 | P03956 | 2/20 | 0.68 |
| ▸ | MMP2 | P08253 | 2/20 | 0.68 |
| ▸ | MMP9 | P14780 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.68 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 1/20 | 0.68 |
| ▸ | CA2 | P00918 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13953735 | 0.89 | BACE1 (0.57) | BACE1KDM4EHSD17B10GAAMAPT | |
| SCHEMBL22902413 | 0.87 | GSK3B (0.81) | BACE1KDM4EHSD17B10GAAMAPT | |
| SCHEMBL5598948 | 0.87 | KDM4E (0.74) | BACE1KDM4EHSD17B10GAAMAPT | |
| SCHEMBL2221673 | 0.87 | KDM4E (0.74) | BACE1KDM4EHSD17B10GAAMAPT | |
| SCHEMBL23260803 | 0.86 | HSD17B10 (0.64) | BACE1KDM4EHSD17B10GAAMAPT | |
| SCHEMBL20978310 | 0.86 | IAPP (0.67) | BACE1KDM4EHSD17B10GAAMAPT | |
| SCHEMBL30851321 | 0.86 | IAPP (0.67) | BACE1KDM4EHSD17B10GAAMAPT | |
| SCHEMBL611054 | 0.85 | BACE1 (0.60) | BACE1KDM4EHSD17B10GAAMAPT | |
| SCHEMBL611055 | 0.85 | BACE1 (0.60) | BACE1KDM4EHSD17B10GAAMAPT | |
| SCHEMBL26555577 | 0.85 | FOS (0.63) | BACE1KDM4EHSD17B10GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017218219-A1 | NOVEL DERIVATIVES OF CURCUMINOIDS AND USE THEREOF AS AN ANTICANCER AGENT | CHINA MEDICAL UNIVERSITY (TW) | 2017-12-21 | — | — | WO | disclosed |
| US-20160039734-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | STC UNM (US) | 2016-02-11 | — | — | US | disclosed |
| US-20150232642-A1 | POLYMERIC NANOPARTICLES COMPRISING TURMERIC | XEROX CORPORATION (US) | 2015-08-20 | — | — | US | disclosed |
| US-20150011494-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | STC.UNM | 2015-01-08 | — | — | US | disclosed |
| US-8841326-B2 | Therapeutic curcumin derivatives | STC.UNM (US) | 2014-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039734-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | FABP2, GLS2, FABP1 | BACE1 750/4885KDM4E 3658/4885HSD17B10 768/4885 |
| US-20150011494-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | FABP2, GLS2, FABP1 | BACE1 750/4885KDM4E 3658/4885HSD17B10 768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.