Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 17/20 | 0.65 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.55 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | MARK3 | P27448 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2335415 | 0.91 | S1PR1 (0.62) | S1PR1S1PR3MAP4K4MINK1PRKCD | |
| SCHEMBL404150 | 0.91 | S1PR1 (0.62) | S1PR1S1PR3MAP4K4MINK1PRKCD | |
| SCHEMBL3741047 | 0.87 | S1PR1 (0.73) | S1PR1S1PR3MAP4K4MINK1PRKCD | |
| SCHEMBL1609855 | 0.85 | S1PR1 (0.54) | S1PR1S1PR3MAP4K4MINK1PRKCD | |
| SCHEMBL13045365 | 0.82 | S1PR1 (0.64) | S1PR1S1PR3MAP4K4MINK1PRKCD | |
| SCHEMBL399937 | 0.82 | S1PR1 (0.63) | S1PR1S1PR3MAP4K4MINK1PRKCD | |
| SCHEMBL1969015 | 0.81 | S1PR1 (0.57) | S1PR1S1PR3 | |
| SCHEMBL2123456 | 0.81 | S1PR1 (0.56) | S1PR1S1PR3 | |
| SCHEMBL1966006 | 0.80 | S1PR1 (0.81) | S1PR1S1PR3MAP4K4MINK1PRKCD | |
| SCHEMBL3741171 | 0.80 | MAP4K4 (0.65) | S1PR1S1PR3MAP4K4MINK1PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217028-B2 | 1,2,4-oxadiazole indole compounds | GLAXO GROUP LIMITED (GB) | 2012-07-10 | — | — | US | disclosed |
| US-20110086839-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-14 | — | — | US | disclosed |
| US-20100029729-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-02-04 | — | — | US | disclosed |
| US-20100010053-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029729-A1 | COMPOUNDS | CYP11B2, CYP11B1, GLS2 | S1PR1 2320/4885S1PR3 1694/4885MAP4K4 3026/4885 |
| US-20100010053-A1 | COMPOUNDS | CYP11B2, CYP11B1, GLS2 | S1PR1 2320/4885S1PR3 1694/4885MAP4K4 3026/4885 |
| US-20110086839-A1 | COMPOUNDS | CYP11B2, CYP11B1, GLS2 | S1PR1 2320/4885S1PR3 1694/4885MAP4K4 3026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.