Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 12/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.31 |
| ▸ | CNR1 | P21554 | 3/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | HTR2B | P41595 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16093969 | 0.82 | CNR2 (0.39) | CNR2SCN9A | |
| SCHEMBL16099644 | 0.81 | THRA (0.45) | CNR2SCN9A | |
| SCHEMBL17433251 | 0.79 | SCN9A (0.45) | CNR2SCN9ACNR1HTR2CHTR2B | |
| SCHEMBL16094368 | 0.78 | CHUK (0.34) | CNR2 | |
| SCHEMBL17418119 | 0.78 | SCN9A (0.42) | CNR2SCN9ACNR1HTR2CHTR2B | |
| SCHEMBL16119902 | 0.78 | SCN9A (0.42) | CNR2SCN9ACNR1HTR2CHTR2B | |
| SCHEMBL17418101 | 0.75 | SCN9A (0.41) | CNR2SCN9A | |
| SCHEMBL17418099 | 0.75 | SCN9A (0.41) | CNR2SCN9A | |
| SCHEMBL16119904 | 0.75 | SCN9A (0.41) | CNR2SCN9A | |
| SCHEMBL16093924 | 0.73 | CNR2 (0.38) | CNR2SCN9ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968280-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |