Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 13/20 | 0.58 |
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.58 |
| ▸ | KDM2B | Q8NHM5 | 6/20 | 0.58 |
| ▸ | KDM5A | P29375 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM5C | P41229 | 2/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16094991 | 0.89 | KDM4C (0.60) | KDM4CKDM5BKDM2BKDM5AKDM4E | |
| SCHEMBL16095312 | 0.82 | KDM4C (0.60) | KDM4CKDM5BKDM2BKDM5AKDM5C | |
| SCHEMBL29723246 | 0.80 | KDM4C (0.67) | KDM4CKDM5BKDM2BKDM5AKDM4E | |
| SCHEMBL28441960 | 0.80 | KDM4C (0.67) | KDM4CKDM5BKDM2BKDM5AKDM4E | |
| SCHEMBL16095288 | 0.78 | KMT2A (0.43) | KDM4EMEN1ALDH1A1GAAHPGD | |
| SCHEMBL1179961 | 0.75 | KDM4E (0.60) | KDM4CKDM5BKDM2BKDM5AKDM4E | |
| Nitrous Acid SCHEMBL29134647 | 0.75 | KDM4C (0.61) | KDM4CKDM5BKDM2BKDM5AKDM4E | |
| SCHEMBL9749306 | 0.74 | HPGD (0.62) | KDM4EMEN1ALDH1A1CYP1A2GLA | |
| SCHEMBL16034442 | 0.74 | KDM4C (1.00) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL15676819 | 0.73 | MAPT (0.56) | KDM4EMEN1ALDH1A1CYP1A2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969007-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals Inc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151945-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |