Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.83 |
| ▸ | MAP1LC3B | Q9GZQ8 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PDE6D | O43924 | 4/20 | 0.44 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 7/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25735274 | 0.95 | KIF11 (0.84) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL644230 | 0.92 | KIF11 (0.75) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL11920179 | 0.92 | KIF11 (0.87) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL10192121 | 0.91 | KIF11 (0.79) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| Sb-743921 SCHEMBL645543 | 0.91 | KIF11 (1.00) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| Sb-743921 SCHEMBL647316 | 0.91 | KIF11 (1.00) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| Sb-743921 SCHEMBL29377772 | 0.91 | KIF11 (1.00) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL13309222 | 0.91 | KIF11 (0.78) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| Sb-743921 SCHEMBL16354067 | 0.90 | KIF11 (0.98) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| Sb-743921 SCHEMBL649759 | 0.90 | KIF11 (0.98) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968591-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | Novartis AG (CH) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151030-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2014-09-25 | — | — | WO | disclosed |