Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.35 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16097815 | 0.84 | SMN1; SMN2 (0.50) | CNR2L3MBTL1SIGMAR1SMN1; SMN2RPS6KA5 | |
| SCHEMBL23331023 | 0.77 | HSD17B10 (0.40) | CNR2L3MBTL1MAPK8MAPK9MAPK10 | |
| SCHEMBL31093334 | 0.76 | ALDH1A1 (0.46) | CNR2L3MBTL1ALDH1A1AKR1C3HTR6 | |
| SCHEMBL22858415 | 0.75 | MAPK8 (0.49) | CNR2MAPK8MAPK9MAPK10PIM1 | |
| SCHEMBL30919743 | 0.75 | ROCK1 (0.49) | L3MBTL1SMN1; SMN2ALDH1A1HSD17B10MAPT | |
| SCHEMBL23330864 | 0.73 | CNR2 (0.36) | CNR2L3MBTL1ALDH1A1HTR6HSD17B10 | |
| SCHEMBL19192016 | 0.73 | IDH1 (0.38) | SMN1; SMN2RPS6KA5RPS6KA4ABL1BCR | |
| SCHEMBL24759988 | 0.73 | CNR2 (0.41) | CNR2L3MBTL1SIGMAR1MAPK8MAPK9 | |
| SCHEMBL27258203 | 0.72 | MAPK8 (0.47) | MAPK8MAPK9MAPK10METROS1 | |
| SCHEMBL25197838 | 0.72 | CNR2 (0.40) | CNR2L3MBTL1SIGMAR1SMN1; SMN2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014147586-A1 | 1-(2-(ETHYLAMINO)PYRIMIDIN-4-YL)PYRROLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH | NOVARTIS AG (CH) | 2014-09-25 | — | — | WO | disclosed |