Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.32 |
| ▸ | ACE | P12821 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16097228 | 0.80 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2HCRTR1HCRTR2ABL1 | |
| SCHEMBL16097225 | 0.80 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2HCRTR1HCRTR2ABL1 | |
| SCHEMBL9104817 | 0.72 | HDAC1 (0.42) | MAPTSMN1; SMN2HCRTR1HDAC1HDAC8 | |
| SCHEMBL9104794 | 0.72 | HDAC1 (0.42) | MAPTSMN1; SMN2HCRTR1HDAC1HDAC8 | |
| SCHEMBL3710014 | 0.72 | P2RX7 (0.39) | P2RX7ACE | |
| SCHEMBL3710013 | 0.72 | P2RX7 (0.39) | P2RX7ACE | |
| SCHEMBL2568372 | 0.72 | NPC1 (0.51) | MAPTSMN1; SMN2KMT2A | |
| SCHEMBL2568370 | 0.72 | NPC1 (0.51) | MAPTSMN1; SMN2KMT2A | |
| SCHEMBL16098502 | 0.70 | MAPT (0.41) | MAPTSMN1; SMN2HCRTR1HCRTR2KMT2A | |
| SCHEMBL16098503 | 0.70 | MAPT (0.41) | MAPTSMN1; SMN2HCRTR1HCRTR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014147586-A1 | 1-(2-(ETHYLAMINO)PYRIMIDIN-4-YL)PYRROLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH | NOVARTIS AG (CH) | 2014-09-25 | — | — | WO | disclosed |