Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | F13A1 | P00488 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | TGM1 | P22735 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | DDIT3 | P35638 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27839480 | 0.88 | USP2 (0.61) | MAPTALDH1A1PKMUSP2SMN1; SMN2 | |
| SCHEMBL6302757 | 0.84 | USP2 (0.68) | MAPTALDH1A1PKMUSP2SMN1; SMN2 | |
| SCHEMBL8726088 | 0.83 | MAPT (0.63) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL10037161 | 0.83 | MAPT (0.63) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL12075773 | 0.83 | MAPT (0.63) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL5018821 | 0.83 | USP2 (0.71) | ALDH1A1USP2SMN1; SMN2 | |
| SCHEMBL11510345 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL29764424 | 0.81 | MAPT (0.69) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL8726108 | 0.81 | MAPT (0.59) | MAPTALDH1A1PKMF13A1TGM2 | |
| SCHEMBL7077124 | 0.81 | MAPT (0.59) | MAPTALDH1A1PKMF13A1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103384668-B | compounds and compositions for inhibition of NAMPT | 福马TM有限责任公司 | 2017-05-31 | — | — | CN | claimed |
| EP-2611804-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031197-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |