Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | GPR183 | P32249 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | F13A1 | P00488 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | TGM1 | P22735 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12075773 | 0.87 | MAPT (0.63) | MAPTALDH1A1PKMUSP2SMN1; SMN2 | |
| SCHEMBL15010487 | 0.85 | USP2 (0.63) | ALDH1A1PKMUSP2GAA | |
| SCHEMBL8726108 | 0.84 | MAPT (0.59) | MAPTALDH1A1IKBKBCHUKPKM | |
| SCHEMBL4555722 | 0.84 | USP2 (0.67) | MAPTUSP2SMN1; SMN2LMNAGAA | |
| SCHEMBL13176134 | 0.81 | LMNA (0.68) | ALDH1A1USP2SMN1; SMN2LMNAGAA | |
| SCHEMBL10037161 | 0.81 | MAPT (0.63) | MAPTALDH1A1PKMUSP2SMN1; SMN2 | |
| SCHEMBL160990 | 0.81 | MAPT (0.63) | MAPTALDH1A1PKMUSP2SMN1; SMN2 | |
| SCHEMBL8726088 | 0.81 | MAPT (0.63) | MAPTALDH1A1PKMUSP2SMN1; SMN2 | |
| SCHEMBL16026487 | 0.80 | ALDH1A1 (0.69) | MAPTALDH1A1PKMUSP2SMN1; SMN2 | |
| SCHEMBL16810277 | 0.80 | MAPT (0.58) | MAPTALDH1A1IKBKBCHUKPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |
| CN-1272107-A | Benzamidine derivatives as factor Xa inhibitors | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| EP-1025086-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999016751-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 1999-04-08 | — | — | WO | disclosed |