Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16100558 | 0.95 | LRRK2 (0.41) | LRRK2INSRIGF1RALKGSK3B | |
| SCHEMBL16120042 | 0.82 | LRRK2 (0.41) | LRRK2INSRIGF1RALKGSK3B | |
| SCHEMBL16099650 | 0.81 | LRRK2 (0.36) | LRRK2INSRIGF1RALKGSK3B | |
| SCHEMBL16120036 | 0.77 | LRRK2 (0.44) | LRRK2INSRIGF1RALKNTRK1 | |
| SCHEMBL16102326 | 0.77 | LRRK2 (0.40) | LRRK2INSRIGF1RALKGSK3B | |
| SCHEMBL17457579 | 0.76 | GSK3B (0.37) | LRRK2INSRIGF1RALKGSK3B | |
| SCHEMBL16102325 | 0.76 | LRRK2 (0.39) | LRRK2INSRIGF1RALKGSK3B | |
| SCHEMBL17457580 | 0.74 | GSK3B (0.35) | LRRK2INSRIGF1RALKGSK3B | |
| SCHEMBL16099736 | 0.74 | HTR2A (0.34) | MAPK1 | |
| SCHEMBL16129427 | 0.73 | PRMT1 (0.47) | LRRK2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970220-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153235-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |