Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | CPT2 | P23786 | 2/20 | 0.34 |
| ▸ | CPT1A | P50416 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16100245 | 0.95 | LRRK2 (0.38) | LRRK2NTRK1PDE4DMAPK1INSR | |
| SCHEMBL16120036 | 0.83 | LRRK2 (0.44) | LRRK2NTRK1MAPK1INSRIGF1R | |
| SCHEMBL16102326 | 0.82 | LRRK2 (0.40) | LRRK2NTRK1CPT2CPT1AMAPK1 | |
| SCHEMBL16102325 | 0.81 | LRRK2 (0.39) | LRRK2NTRK1CPT2CPT1AMAPK1 | |
| SCHEMBL16120042 | 0.77 | LRRK2 (0.41) | LRRK2NTRK1INSRIGF1RALK | |
| SCHEMBL17457575 | 0.77 | LRRK2 (0.38) | LRRK2NTRK1MAPK1GSK3BKCNH2 | |
| SCHEMBL16099650 | 0.77 | LRRK2 (0.36) | LRRK2NTRK1MAPK1INSRIGF1R | |
| SCHEMBL17457577 | 0.74 | LRRK2 (0.38) | LRRK2NTRK1MAPK1GSK3BKCNH2 | |
| SCHEMBL16099736 | 0.72 | HTR2A (0.34) | MAPK1JAK3 | |
| SCHEMBL17457579 | 0.71 | GSK3B (0.37) | LRRK2NTRK1MAPK1INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970220-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153235-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |