Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17418092 | 0.86 | PDE4B (0.44) | SCN9A | |
| SCHEMBL17418090 | 0.86 | PDE4B (0.44) | SCN9A | |
| SCHEMBL16119913 | 0.78 | SCN9A (0.42) | SCN9A | |
| SCHEMBL16119915 | 0.73 | SCN9A (0.73) | SCN9AJAK3 | |
| SCHEMBL17418028 | 0.73 | SCN9A (0.73) | SCN9AJAK3 | |
| SCHEMBL17418067 | 0.70 | SCN9A (0.64) | SCN9ASCN1ASCN5ASCN2ASCN8A | |
| SCHEMBL16094094 | 0.68 | TAAR1 (0.38) | JAK3 | |
| SCHEMBL17433264 | 0.68 | SCN9A (0.64) | SCN9ASCN5A | |
| SCHEMBL16100427 | 0.67 | PDE4B (0.45) | SCN9A | |
| SCHEMBL16100429 | 0.67 | PDE4B (0.45) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968280-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |