Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 5/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17418062 | 0.85 | PDE4B (0.46) | — | |
| SCHEMBL17418061 | 0.85 | PDE4B (0.46) | — | |
| SCHEMBL30606154 | 0.75 | IKBKB (0.38) | IKBKBSCD | |
| SCHEMBL26598674 | 0.75 | IKBKB (0.38) | IKBKBSCD | |
| SCHEMBL25245764 | 0.74 | HSD11B1 (0.40) | JAK3HMOX1CYP4A11CYP4F2 | |
| SCHEMBL25298562 | 0.74 | HSD11B1 (0.40) | JAK3HMOX1CYP4A11CYP4F2 | |
| SCHEMBL15124813 | 0.72 | FFAR4 (0.38) | TAAR1NPC1RAB9ACYP4A11CYP4F2 | |
| SCHEMBL3506878 | 0.72 | FFAR4 (0.38) | TAAR1NPC1RAB9ACYP4A11CYP4F2 | |
| SCHEMBL5274039 | 0.72 | MMP1 (0.44) | PROKR1CYP4A11CYP4F2LIPG | |
| SCHEMBL3505172 | 0.72 | FFAR4 (0.38) | TAAR1NPC1RAB9ACYP4A11CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968280-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |