Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 5/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847160 | 0.80 | TACR1 (0.49) | ADRA1DADRA1AADRA1BMAPTTACR1 | |
| SCHEMBL16302146 | 0.79 | ADRA1D (0.32) | ADRA1DADRA1AADRA1BTACR1 | |
| SCHEMBL16302136 | 0.64 | DAO (0.40) | ADRA1DADRA1AADRA1BDAOMAPT | |
| SCHEMBL13342745 | 0.56 | GRIN2D (0.46) | ALDH1A1TSHR | |
| SCHEMBL3047898 | 0.56 | CYP1A2 (0.62) | DAOALDH1A1TSHRTDP1 | |
| SCHEMBL16358059 | 0.54 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BDAO | |
| SCHEMBL11808887 | 0.53 | GRM2 (0.49) | SLC18A2TDP1 | |
| SCHEMBL66918 | 0.53 | CYP1A2 (0.55) | SLC18A2TDP1 | |
| SCHEMBL27549 | 0.53 | CYP1A2 (0.54) | DAOMAPTALDH1A1TDP1 | |
| Iodide SCHEMBL27615487 | 0.53 | CYP1A2 (0.55) | MAPTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433940-B9 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2015-10-28 | — | — | EP | disclosed |
| EP-2433940-B1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2014-09-24 | — | — | EP | disclosed |
| EP-2433940-A1 | SPIROIMIDAZOLONE DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-03-28 | — | — | EP | disclosed |