Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | CFD | P00746 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16105149 | 1.00 | USP2 (0.47) | USP2KMT2AMEN1NPSR1TSHR | |
| SCHEMBL2542454 | 0.83 | APP (0.49) | USP2KMT2AMEN1NPSR1TSHR | |
| SCHEMBL16105191 | 0.81 | ATM (0.49) | DPP4ALDH1A1 | |
| SCHEMBL16105193 | 0.81 | ATM (0.49) | DPP4ALDH1A1 | |
| SCHEMBL20956773 | 0.78 | CHRM3 (0.41) | DPP4ALDH1A1 | |
| SCHEMBL20956776 | 0.78 | CHRM3 (0.41) | DPP4ALDH1A1 | |
| SCHEMBL13738630 | 0.76 | DPP4 (0.47) | KMT2ADPP4ALDH1A1RIPK1 | |
| SCHEMBL15667954 | 0.76 | DPP4 (0.47) | KMT2ADPP4ALDH1A1RIPK1 | |
| SCHEMBL15608026 | 0.76 | DPP4 (0.47) | KMT2ADPP4ALDH1A1RIPK1 | |
| SCHEMBL5048503 | 0.76 | FFAR1 (0.52) | KMT2AMEN1TSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846694-B2 | Pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2014-09-30 | — | — | US | disclosed |