Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4308226 | 0.85 | PRMT5 (0.50) | FFAR1MCHR1HRH3MCHR2ALDH1A1 | |
| SCHEMBL4308216 | 0.85 | PRMT5 (0.50) | FFAR1MCHR1HRH3MCHR2ALDH1A1 | |
| SCHEMBL9075518 | 0.81 | DPP4 (0.47) | HRH3EPHX1 | |
| SCHEMBL8695496 | 0.81 | DPP4 (0.47) | HRH3EPHX1 | |
| SCHEMBL5413716 | 0.80 | FFAR1 (0.55) | FFAR1HRH3HPGDLTA4HRAB9A | |
| SCHEMBL3946563 | 0.78 | ALDH1A1 (0.50) | FFAR1MCHR1HRH3MCHR2ALDH1A1 | |
| SCHEMBL5314984 | 0.77 | FFAR1 (0.52) | FFAR1MCHR1HRH3MCHR2ALDH1A1 | |
| SCHEMBL16105149 | 0.76 | USP2 (0.47) | ALDH1A1MEN1KMT2AMAPTTSHR | |
| SCHEMBL16105151 | 0.76 | USP2 (0.47) | ALDH1A1MEN1KMT2AMAPTTSHR | |
| SCHEMBL25379093 | 0.76 | MEN1 (0.41) | HRH3MEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926708-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | Decode Chemistry, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007040682-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2007-04-12 | — | — | WO | disclosed |