Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.54 |
| ▸ | MAOB | P27338 | 5/20 | 0.54 |
| ▸ | PLD2 | O14939 | 1/20 | 0.48 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.48 |
| ▸ | VCP | P55072 | 4/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13941522 | 1.00 | MAOA (0.54) | MAOAMAOBPLD2PLD1VCP | |
| SCHEMBL13941381 | 0.91 | EGFR (0.52) | PLD2PLD1PLK4CHEK1AURKA | |
| SCHEMBL13941706 | 0.90 | MAOA (0.54) | MAOAMAOBPLD2PLD1VCP | |
| SCHEMBL13941451 | 0.89 | EGFR (0.56) | PLD2PLD1PLK4CHEK1AURKA | |
| SCHEMBL13941532 | 0.89 | EGFR (0.50) | PLD2PLD1PLK4CHEK1AURKA | |
| SCHEMBL16108828 | 0.89 | EGFR (0.56) | PLD2PLD1PLK4CHEK1AURKA | |
| SCHEMBL13941453 | 0.89 | EGFR (0.58) | PLD2PLD1PLK4CHEK1AURKA | |
| SCHEMBL13941469 | 0.89 | NPC1 (0.55) | MAOAMAOBPLD2PLD1PLK4 | |
| SCHEMBL13941533 | 0.88 | EGFR (0.49) | PLD2PLD1PLK4CHEK1AURKA | |
| SCHEMBL13941552 | 0.87 | NPC1 (0.48) | MAOAMAOBPLD2PLD1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9278089-B2 | Method of treating HCV infection with a small molecule CHK2 inhibitor | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-03-08 | — | — | US | disclosed |
| US-20140294767-A1 | METHOD OF TREATING HCV INFECTION WITH A SMALL MOLECULE CHK2 INHIBITOR | PROVID PHARMACEUTICALS, INC. | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140294767-A1 | METHOD OF TREATING HCV INFECTION WITH A SMALL MOLECULE CHK2 INHIBITOR | CHEK2, CHEK1, CDK2 | MAOA 4780/4885MAOB 4580/4885PLD2 1901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.