Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8409590 | 1.00 | — | — | |
| Bromide SCHEMBL28090127 | 0.87 | — | — | |
| Bromide SCHEMBL9258329 | 0.82 | CA1 (0.50) | — | |
| Bromide SCHEMBL19716 | 0.82 | — | — | |
| SCHEMBL28871344 | 0.82 | — | — | |
| Bromide SCHEMBL8468244 | 0.82 | — | — | |
| Bromide SCHEMBL14690681 | 0.82 | — | — | |
| SCHEMBL286246 | 0.82 | — | — | |
| Bromide SCHEMBL7172901 | 0.82 | — | — | |
| Bromide SCHEMBL2195416 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108276396-A | A method of synthesis ipragliflozin | 安庆奇创药业有限公司 | 2018-07-13 | — | — | CN | claimed |
| EP-2488515-B1 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT2 | JANSSEN PHARMACEUTICA NV (BE) | 2017-01-04 | — | — | EP | claimed |
| US-9174971-B2 | Process for the preparation of compounds useful as inhibitors of SGLT2 | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-03 | — | — | US | claimed |
| CN-102648196-A | Process for the preparation of compounds useful as inhibitors of SGLT2 | JANSSEN PHARMACEUTICA NV | 2012-08-22 | — | — | CN | claimed |
| US-20110087017-A1 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT2 | JANSSEN PHARMACEUTICA NV (BE) | 2011-04-14 | — | — | US | claimed |
| CN-116239643-A | Engliflozin intermediate compound | 山东新时代药业有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-116239583-A | Synthetic method of enggliflozin | 山东新时代药业有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-116239582-A | Engliflozin intermediate compound and preparation method thereof | 山东新时代药业有限公司 | 2023-06-09 | — | — | CN | disclosed |
| EP-2963048-B1 | METHOD FOR PRODUCING ALPHA-HALO-TETRAACYL GLUCOSE | MITSUBISHI TANABE PHARMA CORP (JP) | 2020-11-18 | — | — | EP | disclosed |
| US-20190048034-A1 | METHOD FOR PRODUCING ALPHA-HALO-TETRAACYL-GLUCOSE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2019-02-14 | — | — | US | disclosed |
| CN-108276396-A | A method of synthesis ipragliflozin | 安庆奇创药业有限公司 | 2018-07-13 | — | — | CN | disclosed |
| CN-105008379-B | The manufacturing method of four acyl glucose of alpha-halogenate | 田边三菱制药株式会社 | 2018-06-29 | — | — | CN | disclosed |
| US-20160002276-A1 | METHOD FOR PRODUCING a-HALO-TETRAACYL-GLUCOSE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2016-01-07 | — | — | US | disclosed |
| EP-2963048-A1 | METHOD FOR PRODUCING -HALO-TETRAACYL GLUCOSE | Mitsubishi Tanabe Pharma Corporation (JP) | 2016-01-06 | — | — | EP | disclosed |
| CN-105008379-A | METHOD FOR PRODUCING [Alpha]-HALO-TETRAACYL GLUCOSE | MITSUBISHI TANABE PHARMA CORP | 2015-10-28 | — | — | CN | disclosed |