Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 17/20 | 0.61 |
| ▸ | ACVR1 | Q04771 | 17/20 | 0.61 |
| ▸ | BMPR1A | P36894 | 15/20 | 0.61 |
| ▸ | BMPR1B | O00238 | 14/20 | 0.61 |
| ▸ | ACVR1B | P36896 | 13/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.49 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.49 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.49 |
| ▸ | BMP4 | P12644 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112112 | 0.95 | ACVR1B (0.60) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL16112553 | 0.92 | ACVRL1 (0.61) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL16134959 | 0.82 | ACVRL1 (0.70) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL17531641 | 0.77 | ACVRL1 (0.84) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL16134991 | 0.77 | ACVR1B (0.69) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL16134963 | 0.76 | ACVR1 (1.00) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL23988936 | 0.75 | ACVR1 (0.68) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL16111945 | 0.75 | ACVRL1 (0.69) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL16111725 | 0.74 | ACVRL1 (0.74) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL16112505 | 0.74 | ACVRL1 (0.70) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970311-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | The Brigham and Women's Hospital, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014160203-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2014-10-02 | — | — | WO | disclosed |