Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | TLR2 | O60603 | 1/20 | 0.59 |
| ▸ | ERN1 | O75460 | 1/20 | 0.59 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.59 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TFEB | P19484 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665129 | 0.93 | SRC (0.59) | SRCTLR2ERN1TLR1TLR6 | |
| SCHEMBL807200 | 0.88 | TLR2 (0.62) | SRCTLR2ERN1TLR1TLR6 | |
| SCHEMBL16048364 | 0.88 | SRC (0.60) | SRCTLR2ERN1TLR1TLR6 | |
| SCHEMBL16072692 | 0.88 | SRC (0.54) | SRCTLR2ERN1TLR1TLR6 | |
| SCHEMBL4645064 | 0.87 | SRC (0.59) | SRCTLR2ERN1TLR1TLR6 | |
| SCHEMBL4642146 | 0.85 | SRC (0.57) | SRCTLR2ERN1TLR1TLR6 | |
| SCHEMBL24810562 | 0.84 | SRC (0.56) | SRCTLR2ERN1TLR1TLR6 | |
| SCHEMBL4645165 | 0.84 | SRC (0.56) | SRCTLR2ERN1TLR1TLR6 | |
| SCHEMBL3308881 | 0.84 | SRC (0.56) | SRCTLR2ERN1TLR1TLR6 | |
| O-Veratraldehyde SCHEMBL29923149 | 0.83 | SRC (0.67) | SRCTLR2ERN1TLR1TLR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920029-B2 | Isatin compounds, compositions and methods for treatment of degenerative diseases and disorders | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2018-03-20 | — | — | US | disclosed |
| EP-2970183-A2 | ISATIN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | Musc Foundation for Research Development (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20150218128-A1 | Isatin Compounds, Compositions And Methods For Treatment Of Degenerative Diseases And Disorders | MUSC Foundation for Research Development (10 pp.) | 2015-08-06 | — | — | US | disclosed |
| WO-2014160143-A2 | ISATIN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2014-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218128-A1 | Isatin Compounds, Compositions And Methods For Treatment Of Degenerative Diseases And Disorders | CLN6, AREG, HASPIN | SRC 3730/4885TLR2 4421/4885ERN1 1258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.