AREG — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL10021369	0.73	4/20
SCHEMBL10052772	0.54	4/20
SCHEMBL8385012	0.56	3/20
SCHEMBL29964993	0.43	2/20
SCHEMBL6919160	0.41	2/20
SCHEMBL10021367	0.75	1/20
SCHEMBL10052528	0.75	1/20
SCHEMBL10021368	0.66	1/20
SCHEMBL10052673	0.66	1/20
SCHEMBL8382805	0.55	1/20
SCHEMBL9171332	0.49	1/20
SCHEMBL6920539	0.44	1/20
SCHEMBL6369530	0.42	1/20
SCHEMBL6820388	0.42	1/20
SCHEMBL12125014	0.42	1/20
SCHEMBL12992250	0.42	1/20
SCHEMBL13545530	0.42	1/20
SCHEMBL28935802	0.42	1/20
SCHEMBL16868490	0.40	1/20

Clinical trials — most relevant to AREG by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Ulipristal Versus Placebo for Women With Bleeding Induced by Mirena	PHASE4	UNKNOWN
The Efficacy and Safety of Inpegsomatropin Injection in Children With Short Stature Born Small for Gestational Age	PHASE3	RECRUITING
Nintedanib in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome Grade 0p-1-2	PHASE3	COMPLETED
Cetuximab & Celecoxib for Metastatic Colorectal Cancer or Colorectal Cancer That Cannot Be Removed by Surgery	PHASE2	COMPLETED
Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer	PHASE2	COMPLETED
Effects of rhIGF-1 on Bone Metabolism in Adolescent Girls With Anorexia Nervosa	PHASE2	COMPLETED
Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)	PHASE2	ACTIVE_NOT_RECRUITING
Development of a Fluorescent Visualization System for Non-visible Lung Cancer Nodules	PHASE2	UNKNOWN
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
Platelet Rich Plasma and Diabetic Foot Ulcer	PHASE2	COMPLETED
Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome	PHASE1/PHASE2	COMPLETED
Glucocorticoid Induced Whole Body Catabolisme	PHASE2	COMPLETED
Type 2 Innate Lymphoid Cells in Severe Pediatric Asthma	nan	WITHDRAWN
Studies of Neuregulin/ERBB Signaling in Human Heart	nan	RECRUITING
Study of Tissue, Blood, and Urine Samples From Patients With Advanced Prostate Cancer	nan	UNKNOWN
Neuregulin-1 in Patient With Different Forms of Cardiovascular Diseases: a Pilot Study	nan	COMPLETED
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)	nan	COMPLETED
Platelet Rich Plasma Versus Placebo for the Treatment of Greater Trochanteric Pain Syndrome (HiPPO Trial)	nan	COMPLETED
Comparison of Two Different Types of Platelet Concentrate to Augment Bone Around Immediate Dental Implant	nan	COMPLETED
TNFα and MFG-E8: Novel Biomarkers to Predict Implantation Failure	nan	COMPLETED
Biomarkers in the Diagnosis and Prognosis of NAFLD	nan	RECRUITING
The Role of Gene Changes in Brain Tumor Formation and Growth	nan	COMPLETED
Nutritional Management of Acute and Chronic Enterocutaneous Fistulae	nan	UNKNOWN
Intrauterine Infusion of GCSF and Reproductive Outcomes in Infertile Women with History of RIF	nan	COMPLETED
Understanding Immunotherapy Resistance Mechanisms in Advanced Melanoma	nan	COMPLETED
Relationship Between Obesity and Periodontal Disease	nan	COMPLETED
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle	nan	UNKNOWN
Improvements in Aerobic Fitness With Exercise Training: the Role of Myokines	nan	COMPLETED
Growth Factors and Hepatic Progenitor Cells in Acute Liver Failure	nan	UNKNOWN
Combined LASERs and PRP for Postacne Scars	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AREG binder may also engage these)

Protein	Name	Similarity
P31955	—	1.000	P31955 →
P24338	—	0.997	P24338 →
Q9W7C5	—	0.993	Q9W7C5 →
Q06175	—	0.991	Q06175 →
Q09118	—	0.991	Q09118 →
P34900	—	0.991	P34900 →
Q06186	—	0.991	Q06186 →
Q9D9J7	—	0.991	Q9D9J7 →
Q03345	—	0.990	Q03345 →
Q14CH0	—	0.990	Q14CH0 →
Q95M19	—	0.990	Q95M19 →
A6QP06	—	0.990	A6QP06 →
Q6GR51	—	0.989	Q6GR51 →
Q96FE7	—	0.989	Q96FE7 →
P14221	—	0.989	P14221 →
Q6P995	—	0.989	Q6P995 →
Q5RCS3	—	0.989	Q5RCS3 →
Q56A20	—	0.989	Q56A20 →
Q7TMJ8	—	0.989	Q7TMJ8 →
Q6RZT5	—	0.989	Q6RZT5 →
P43407	—	0.989	P43407 →
Q640L3	—	0.989	Q640L3 →
Q9BZD6	—	0.989	Q9BZD6 →
Q01580	—	0.989	Q01580 →
Q99075	—	0.989	Q99075 →
P35054	—	0.988	P35054 →
Q9Z2U2	—	0.988	Q9Z2U2 →
Q92183	—	0.988	Q92183 →
P01136	—	0.988	P01136 →
P43322	—	0.988	P43322 →