Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 5/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838375 | 0.97 | HPGD (0.41) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16113298 | 0.87 | NR1H2 (0.40) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL24693756 | 0.85 | HPGD (0.48) | HPGDUSP2SMN1; SMN2GPR119EPHX1 | |
| SCHEMBL18838373 | 0.85 | HPGD (0.48) | HPGDUSP2SMN1; SMN2GPR119EPHX1 | |
| SCHEMBL17107694 | 0.84 | NR1H2 (0.40) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL30744670 | 0.84 | HPGD (0.42) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL24938934 | 0.84 | HPGD (0.42) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL15769569 | 0.82 | HPGD (0.47) | HPGDUSP2SMN1; SMN2GPR119EPHX1 | |
| SCHEMBL23826942 | 0.82 | HPGD (0.47) | HPGDUSP2SMN1; SMN2GPR119EPHX1 | |
| SCHEMBL28622796 | 0.82 | HPGD (0.47) | HPGDUSP2SMN1; SMN2GPR119EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970200-A1 | PYRIDINE CDK9 KINASE INHIBITORS | Abbvie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014160017-A1 | PYRIDINE CDK9 KINASE INHIBITORS | ABBVIE INC. (US) | 2014-10-02 | — | — | WO | disclosed |