Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112298 | 0.91 | MAPT (0.44) | PLK4AURKADYRK3MAP4K4NTRK1 | |
| SCHEMBL16112722 | 0.89 | RET (0.44) | PLK4AURKADYRK3MAP4K4NTRK1 | |
| SCHEMBL16111712 | 0.85 | RET (0.57) | PLK4AURKADYRK3MAP4K4NTRK1 | |
| SCHEMBL16112667 | 0.80 | CYP4F2 (0.54) | PLK4AURKADYRK3MAP4K4NTRK1 | |
| SCHEMBL17531629 | 0.76 | PRKAB2 (0.52) | PLK4AURKADYRK3MAP4K4NTRK1 | |
| SCHEMBL16112600 | 0.76 | PLK4 (0.47) | PLK4AURKADYRK3MAP4K4NTRK1 | |
| SCHEMBL16134907 | 0.76 | RET (0.56) | PLK4AURKADYRK3MAP4K4NTRK1 | |
| SCHEMBL16112583 | 0.74 | RET (0.57) | RET | |
| SCHEMBL20856536 | 0.72 | MAPT (0.63) | MAPTALDH1A1GAAIDEHRH2 | |
| SCHEMBL16026085 | 0.72 | RET (0.58) | PLK4AURKADYRK3MAP4K4NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970311-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | The Brigham and Women's Hospital, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014160203-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2014-10-02 | — | — | WO | disclosed |