Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1B | P36896 | 15/20 | 0.74 |
| ▸ | ACVR1 | Q04771 | 15/20 | 0.74 |
| ▸ | ACVRL1 | P37023 | 14/20 | 0.74 |
| ▸ | BMPR1B | O00238 | 12/20 | 0.74 |
| ▸ | BMPR1A | P36894 | 11/20 | 0.74 |
| ▸ | BMP4 | P12644 | 5/20 | 0.59 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.55 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.55 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.55 |
| ▸ | BMPR2 | Q13873 | 3/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.51 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16111725 | 0.94 | ACVRL1 (0.74) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A | |
| SCHEMBL16112581 | 0.89 | ACVR1B (0.68) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A | |
| SCHEMBL16112582 | 0.89 | ACVR1B (0.68) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A | |
| SCHEMBL17531623 | 0.86 | ACVR1B (0.81) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A | |
| SCHEMBL24409667 | 0.85 | ACVR1 (1.00) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A | |
| SCHEMBL16134982 | 0.85 | ACVR1 (1.00) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A | |
| SCHEMBL16134893 | 0.83 | ACVRL1 (0.68) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A | |
| SCHEMBL17509648 | 0.83 | ACVRL1 (0.68) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A | |
| SCHEMBL17509657 | 0.80 | ACVR1 (0.67) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A | |
| SCHEMBL19611370 | 0.80 | ACVR1 (0.67) | ACVR1BACVR1ACVRL1BMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970311-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | The Brigham and Women's Hospital, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014160203-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2014-10-02 | — | — | WO | disclosed |