SCHEMBL16112899

SCHEMBL16112899

CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(OCC(F)(F)F)ccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.48
ANO1 Q5XXA6 6/20 0.46
MAPT P10636 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
KMT2A Q03164 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
AR P10275 1/20 0.41
CYP3A4 P08684 6/20 0.41
CYP2C8 P10632 2/20 0.41
KCNH2 Q12809 1/20 0.41
CNR1 P21554 2/20 0.40
CNR2 P34972 2/20 0.40
BCHE P06276 1/20 0.40
CYP2C9 P11712 3/20 0.40
CYP2C19 P33261 3/20 0.40
ALOX15 P16050 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2837609 0.92 ANO1 (0.55) ALDH1A1ANO1KDM4ELMNAHTT
SCHEMBL16114278 0.84 ALDH1A1 (0.42) ALDH1A1ANO1CYP3A4CYP2C8KCNH2
SCHEMBL6841580 0.83 ANO1 (0.43) ANO1CYP3A4KCNH2CYP2C9CYP2C19
SCHEMBL16114356 0.83 CYP3A4 (0.39) ALDH1A1ANO1CYP3A4CYP2C8KCNH2
SCHEMBL2843645 0.82 KDM4E (0.59) ALDH1A1ANO1SMN1; SMN2KDM4EMEN1
SCHEMBL16112837 0.81 CYP3A4 (0.40) ALDH1A1CYP3A4CYP2C8KCNH2CYP2C9
SCHEMBL18809405 0.80 CYP3A4 (0.44) ANO1CYP3A4CYP2C8KCNH2CNR1
SCHEMBL16113732 0.79 CYP3A4 (0.44) CYP3A4KCNH2CYP2C9CYP2C19
SCHEMBL1918391 0.78 KDM4E (0.59) ALDH1A1ANO1KDM4EMEN1LMNA
SCHEMBL18809672 0.78 CYP3A4 (0.46) CYP3A4CYP2C8KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2970174-A1 FUSED FURANS FOR THE TREATMENT OF HEPATITIS C Bristol-Myers Squibb Company (US) 2016-01-20 EP disclosed
WO-2014159559-A1 FUSED FURANS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2014-10-02 WO disclosed