Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 5/20 | 0.59 |
| ▸ | NUDT1 | P36639 | 6/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | IGF1R | P08069 | 2/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.54 |
| ▸ | IKBKB | O14920 | 2/20 | 0.54 |
| ▸ | CHUK | O15111 | 2/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2240671 | 0.80 | AURKB (0.71) | PRKCINUDT1AURKBJAK2PRKACA | |
| SCHEMBL1838740 | 0.79 | CDK5 (0.64) | PRKCINUDT1AURKBJAK2PRKACA | |
| SCHEMBL12354979 | 0.79 | PRKCI (0.58) | PRKCINUDT1AURKBJAK2PRKACA | |
| SCHEMBL12347396 | 0.79 | BRAF (0.60) | PRKCINUDT1AURKBJAK2PRKACA | |
| SCHEMBL3255183 | 0.79 | PRKCI (0.58) | PRKCINUDT1AURKBJAK2PRKACA | |
| SCHEMBL12127819 | 0.76 | PRKCI (0.63) | PRKCINUDT1AURKBJAK2PRKACA | |
| SCHEMBL1719341 | 0.76 | PRKCI (0.63) | PRKCINUDT1AURKBJAK2PRKACA | |
| SCHEMBL1718593 | 0.76 | PRKCI (0.63) | PRKCINUDT1AURKBJAK2PRKACA | |
| SCHEMBL2238760 | 0.76 | BRAF (0.61) | PRKCINUDT1AURKBJAK2PRKACA | |
| SCHEMBL12127208 | 0.75 | PRKCI (1.00) | PRKCINUDT1AURKBJAK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105026393-A | Cdk9 kinase inhibitors | ABBVIE INC | 2015-11-04 | — | — | CN | claimed |
| EP-2970268-A1 | CDK9 KINASE INHIBITORS | AbbVie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| CN-105026393-A | Cdk9 kinase inhibitors | ABBVIE INC | 2015-11-04 | — | — | CN | disclosed |
| WO-2014159999-A1 | CDK9 KINASE INHIBITORS | ABBVIE INC. (US) | 2014-10-02 | — | — | WO | disclosed |