Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.61 |
| ▸ | PRKCI | P41743 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12347396 | 0.81 | BRAF (0.60) | BRAFPRKCIJAK2PRKACAJAK3 | |
| SCHEMBL12572868 | 0.81 | DYRK1A (0.65) | JAK2PRKACAJAK3FLT3GSK3B | |
| SCHEMBL12127819 | 0.79 | PRKCI (0.63) | BRAFPRKCIJAK2PRKACAJAK3 | |
| SCHEMBL12354979 | 0.78 | PRKCI (0.58) | BRAFPRKCIJAK2PRKACAJAK3 | |
| SCHEMBL1838740 | 0.78 | CDK5 (0.64) | BRAFPRKCIJAK2PRKACAJAK3 | |
| SCHEMBL3255183 | 0.78 | PRKCI (0.58) | BRAFPRKCIJAK2PRKACAJAK3 | |
| SCHEMBL3244159 | 0.77 | BRAF (0.60) | BRAFPRKCIJAK2PRKACAJAK3 | |
| SCHEMBL16113151 | 0.76 | PRKCI (0.59) | BRAFPRKCIJAK2PRKACAJAK3 | |
| SCHEMBL2240671 | 0.76 | AURKB (0.71) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL15232070 | 0.75 | CCNA2 (0.46) | BRAFJAK2JAK3CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | BRAF 305/4885PRKCI 387/4885JAK2 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.