Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493526 | 0.93 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1610585 | 0.93 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1612426 | 0.92 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1493323 | 0.92 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1611368 | 0.92 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL1611638 | 0.90 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1493383 | 0.90 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1612063 | 0.90 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1612775 | 0.89 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1493285 | 0.89 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | ALDH1A1 3233/4885SMN1; SMN2 4215/4885LMNA 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.