Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 6/20 | 0.68 |
| ▸ | NT5E | P21589 | 1/20 | 0.68 |
| ▸ | GSK3A | P49840 | 2/20 | 0.64 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | TGM2 | P21980 | 1/20 | 0.62 |
| ▸ | PNP | P00491 | 1/20 | 0.61 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | KRAS | P01116 | 3/20 | 0.56 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16114085 | 1.00 | HINT1 (0.68) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL8064383 | 1.00 | HINT1 (0.68) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL13833305 | 1.00 | HINT1 (0.68) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL8064372 | 1.00 | HINT1 (0.68) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL16114035 | 1.00 | HINT1 (0.68) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| Phosphoric Acid SCHEMBL1971262 | 0.96 | NT5E (0.72) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| Guanosine SCHEMBL24049416 | 0.91 | HPGD (0.76) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| Guanosine SCHEMBL24049608 | 0.91 | HPGD (0.76) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| Guanosine SCHEMBL7062800 | 0.91 | HPGD (0.76) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| Guanosine SCHEMBL24049417 | 0.91 | HPGD (0.76) | HINT1NT5EGSK3ARPS6KA3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970360-A1 | RAS INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014160200-A9 | RAS INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-11-27 | — | — | WO | disclosed |
| WO-2014160200-A1 | RAS INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-10-02 | — | — | WO | disclosed |