Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 10/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16116306 | 0.88 | CREBBP (0.43) | CYP1A2CYP2C19ELANEGRIN1GRIN2B | |
| SCHEMBL16116377 | 0.84 | NR4A2 (0.47) | LDHANPSR1LMNA | |
| SCHEMBL16115373 | 0.81 | EZH2 (0.38) | CYP1A2CYP2C19GRIN2B | |
| SCHEMBL16116059 | 0.78 | NR4A2 (0.53) | CFTRLMNASMN1; SMN2 | |
| SCHEMBL17970391 | 0.74 | MGLL (0.35) | CFTRNPSR1LMNASMN1; SMN2 | |
| SCHEMBL16116199 | 0.74 | EZH2 (0.49) | LMNASMN1; SMN2 | |
| SCHEMBL2587224 | 0.73 | KDM4E (0.41) | CYP1A2CYP2C19 | |
| SCHEMBL2591110 | 0.73 | MAPT (0.40) | SMN1; SMN2 | |
| SCHEMBL16115713 | 0.72 | MAPT (0.44) | SMN1; SMN2 | |
| SCHEMBL16115144 | 0.71 | PTPN1 (0.42) | LDHAAKR1C3AKR1C2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014155301-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS INHIBITORS OF EZH2 | Piramal Enterprises Limited (IN) | 2014-10-02 | — | — | WO | disclosed |