Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 7/20 | 0.67 |
| ▸ | CDK8 | P49336 | 7/20 | 0.67 |
| ▸ | CDC7 | O00311 | 8/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16115139 | 0.87 | PDE3B (0.53) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL11078652 | 0.82 | CDC7 (0.61) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL16115909 | 0.82 | MMP13 (0.58) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL16115194 | 0.80 | CCNC (1.00) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL11237847 | 0.77 | PDE3B (0.60) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL16115636 | 0.77 | CCNC (1.00) | CCNCCDK8CDC7 | |
| SCHEMBL11232233 | 0.75 | PDE3B (0.66) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL11106121 | 0.73 | PDE3B (0.66) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL11238746 | 0.72 | PDE3B (0.64) | CCNCCDK8CDC7PDE3BPDE3A | |
| SCHEMBL11234122 | 0.71 | PDE3B (0.56) | CCNCCDK8CDC7PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014154723-A1 | NOVEL PYRROLE DERIVATIVES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-02 | — | — | WO | claimed |
| WO-2014154723-A1 | NOVEL PYRROLE DERIVATIVES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014154723-A1 | NOVEL PYRROLE DERIVATIVES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-02 | — | — | WO | disclosed |