Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.68 |
| ▸ | CDK8 | P49336 | 2/20 | 0.68 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.49 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1254366 | 0.84 | NR4A2 (0.54) | CCNCCDK8NR4A2CYP1A2CYP2C19 | |
| SCHEMBL31454230 | 0.84 | CCNC (0.62) | CCNCCDK8NR4A2AURKATTK | |
| SCHEMBL12582220 | 0.83 | NR4A2 (0.46) | CCNCCDK8NR4A2CYP1A2CYP2C19 | |
| SCHEMBL31454214 | 0.82 | NR4A2 (0.59) | CCNCCDK8NR4A2CYP2C19ALDH1A1 | |
| SCHEMBL16115664 | 0.82 | CCNC (0.73) | CCNCCDK8NR4A2AURKATTK | |
| SCHEMBL13987886 | 0.81 | CCNC (0.46) | CCNCCDK8NR4A2CYP1A2CYP2C19 | |
| SCHEMBL2025582 | 0.81 | CCNC (0.48) | CCNCCDK8NR4A2CYP1A2CYP2C19 | |
| SCHEMBL16115074 | 0.81 | CCNC (1.00) | CCNCCDK8NR4A2AURKATTK | |
| SCHEMBL16691882 | 0.79 | CYP1A2 (0.44) | CCNCCDK8NR4A2CYP1A2CYP2C19 | |
| SCHEMBL25197344 | 0.78 | CCNC (0.41) | CCNCCDK8NR4A2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119365460-A | Compounds that interact with Ras superfamily proteins for the treatment of cancer, inflammatory diseases, RAS diseases, and fibrotic diseases | 尚医治疗有限责任公司 | 2025-01-24 | — | — | CN | disclosed |
| WO-2014154723-A1 | NOVEL PYRROLE DERIVATIVES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014154723-A1 | NOVEL PYRROLE DERIVATIVES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-02 | — | — | WO | disclosed |