Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12582220 | 0.85 | NR4A2 (0.46) | NR4A2POLBKMT2ACYP1A2CYP2C19 | |
| SCHEMBL16115993 | 0.84 | CCNC (0.68) | NR4A2CYP1A2CYP2C19PKMCCNC | |
| SCHEMBL2025582 | 0.84 | CCNC (0.48) | NR4A2MEN1POLBKMT2ABRD4 | |
| SCHEMBL1126661 | 0.83 | P2RY12 (0.51) | MEN1POLBKMT2ABRD4CYP1A2 | |
| SCHEMBL1126815 | 0.82 | BRD4 (0.58) | NR4A2MEN1POLBKMT2ABRD4 | |
| SCHEMBL31454214 | 0.82 | NR4A2 (0.59) | NR4A2CYP2C19CCNCCDK8GABRA1 | |
| SCHEMBL17266950 | 0.81 | MAPT (0.45) | NR4A2KMT2ABRD4CYP1A2CYP2C19 | |
| SCHEMBL16691882 | 0.81 | CYP1A2 (0.44) | NR4A2CYP1A2CYP2C19PKMCCNC | |
| Biphenyl SCHEMBL27274937 | 0.80 | KDM4E (0.48) | NR4A2MEN1POLBKMT2ABRD4 | |
| SCHEMBL14252698 | 0.79 | LDHA (0.45) | NR4A2MEN1POLBKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268862-B2 | Sirtuin modulating compounds | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20110152254-A1 | SIRTUIN MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| US-7893086-B2 | Sirtuin modulating compounds | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090105246-A1 | Sirtuin modulating compounds | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152254-A1 | SIRTUIN MODULATING COMPOUNDS | SIRT1, SIRT3, SIRT2 | NR4A2 1611/4885MEN1 3137/4885POLB 1951/4885 |
| US-20090105246-A1 | Sirtuin modulating compounds | SIRT1, SIRT3, SIRT2 | NR4A2 1611/4885MEN1 3137/4885POLB 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.