Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.61 |
| ▸ | EZH1 | Q92800 | 6/20 | 0.61 |
| ▸ | EED | O75530 | 5/20 | 0.60 |
| ▸ | SUZ12 | Q15022 | 5/20 | 0.60 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.60 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.60 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16116293 | 0.92 | EZH1 (0.64) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16116240 | 0.92 | EZH2 (0.71) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16116238 | 0.85 | EZH2 (0.71) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16116259 | 0.85 | EZH2 (0.71) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16116209 | 0.84 | EZH1 (0.71) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115485 | 0.82 | EZH2 (0.72) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115031 | 0.81 | EZH2 (0.68) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16116124 | 0.81 | EZH2 (0.68) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115294 | 0.81 | EZH2 (0.58) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115764 | 0.80 | EZH2 (0.69) | EZH2EZH1EEDSUZ12RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014155301-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS INHIBITORS OF EZH2 | Piramal Enterprises Limited (IN) | 2014-10-02 | — | — | WO | claimed |
| WO-2014155301-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS INHIBITORS OF EZH2 | Piramal Enterprises Limited (IN) | 2014-10-02 | — | — | WO | disclosed |