Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.66 |
| ▸ | MAP4K3 | Q8IVH8 | 6/20 | 0.66 |
| ▸ | JAK2 | O60674 | 5/20 | 0.66 |
| ▸ | JAK3 | P52333 | 3/20 | 0.66 |
| ▸ | PLK4 | O00444 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 2/20 | 0.66 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.66 |
| ▸ | INSR | P06213 | 2/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | FES | P07332 | 2/20 | 0.66 |
| ▸ | CSF1R | P07333 | 2/20 | 0.66 |
| ▸ | LYN | P07948 | 2/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.66 |
| ▸ | IGF1R | P08069 | 2/20 | 0.66 |
| ▸ | ROS1 | P08922 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581859 | 0.91 | MET (0.71) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL1902039 | 0.89 | MET (0.73) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL1581558 | 0.89 | MET (0.73) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL16245273 | 0.89 | MET (0.73) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL30753163 | 0.89 | MET (0.73) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL3390547 | 0.88 | MET (0.68) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL1581764 | 0.87 | MET (0.75) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL1582503 | 0.87 | MET (0.75) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL3422594 | 0.87 | MET (0.75) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL3388109 | 0.86 | MET (0.71) | METALKMAP4K3JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014146486-A1 | THREE-LEVEL CYCLIC AMINE ALK KINASE INHIBITOR FOR TREATING CANCER | 浙江导明医药科技有限公司 (CN) | 2014-09-25 | — | — | WO | disclosed |