Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.41 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 7/20 | 0.56 |
| ▸ | HTR2A | P28223 | 6/20 | 0.56 |
| ▸ | HTR2B | P41595 | 6/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.51 |
| ▸ | PRCP | P42785 | 4/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL163850 | 0.98 | HTR2C (0.57) | HTR2CHTR2AHTR2BTAAR1PRCP | |
| SCHEMBL162669 | 0.98 | HTR2C (0.57) | HTR2CHTR2AHTR2BTAAR1PRCP | |
| Iodide SCHEMBL162026 | 0.97 | HTR2C (0.56) | HTR2CHTR2AHTR2BTAAR1PRCP | |
| Phosphoric Acid SCHEMBL166016 | 0.90 | HTR2C (0.49) | HTR2CHTR2AHTR2BTAAR1PRCP | |
| Succinic Acid SCHEMBL161276 | 0.87 | TAAR1 (0.47) | HTR2CHTR2AHTR2BTAAR1PRCP | |
| Nitric Acid SCHEMBL163517 | 0.87 | HTR2C (0.47) | HTR2CHTR2AHTR2BTAAR1PRCP | |
| Malonic Acid SCHEMBL160930 | 0.87 | TAAR1 (0.47) | HTR2CHTR2AHTR2BTAAR1PRCP | |
| SCHEMBL158569 | 0.87 | HTR2C (0.50) | HTR2CHTR2AHTR2BTAAR1PRCP | |
| Glycolic Acid SCHEMBL162065 | 0.87 | TAAR1 (0.47) | HTR2CHTR2AHTR2BTAAR1PRCP | |
| Fumaric Acid SCHEMBL159722 | 0.86 | TAAR1 (0.46) | HTR2CHTR2AHTR2BTAAR1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030953-A1 | 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |