Phosphoric Acid

Phosphoric Acid

SCHEMBL166016

ClC[C@@H]1CNCCc2ccccc21.O=P(O)(O)O

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
OPRM1 known ✓ P35372 4/20 0.39
OPRK1 known ✓ P41145 3/20 0.38
OPRD1 known ✓ P41143 2/20 0.38
HTR2C P28335 4/20 0.49
HTR2A P28223 3/20 0.49
HTR2B P41595 3/20 0.49
TAAR1 Q96RJ0 2/20 0.46
ACP3 P15309 1/20 0.44
TSHR P16473 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
DRD1 P21728 3/20 0.38
DRD2 P14416 2/20 0.38
PDPK1 O15530 1/20 0.38
DRD5 P21918 1/20 0.36
PRCP P42785 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL162669 0.91 HTR2C (0.57) HTR2CHTR2AHTR2BTAAR1PRCP
SCHEMBL163850 0.91 HTR2C (0.57) HTR2CHTR2AHTR2BTAAR1PRCP
Bromide SCHEMBL161200 0.90 HTR2C (0.56) HTR2CHTR2AHTR2BTAAR1PRCP
Iodide SCHEMBL162026 0.90 HTR2C (0.56) HTR2CHTR2AHTR2BTAAR1PRCP
Nitric Acid SCHEMBL163517 0.86 HTR2C (0.47) HTR2CHTR2AHTR2BTAAR1TSHR
SCHEMBL158569 0.86 HTR2C (0.50) HTR2CHTR2AHTR2BTAAR1TSHR
Glycolic Acid SCHEMBL162065 0.86 TAAR1 (0.47) HTR2CHTR2AHTR2BTAAR1TSHR
Malonic Acid SCHEMBL160930 0.86 TAAR1 (0.47) HTR2CHTR2AHTR2BTAAR1TSHR
Succinic Acid SCHEMBL161276 0.86 TAAR1 (0.47) HTR2CHTR2AHTR2BTAAR1TSHR
Fumaric Acid SCHEMBL159722 0.85 TAAR1 (0.46) HTR2CHTR2AHTR2BTAAR1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2611449-A1 ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT Arena Pharmaceuticals, Inc. (US) 2013-07-10 EP disclosed
WO-2012030953-A1 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL ARENA PHARMACEUTICALS, INC. (US) 2012-03-08 WO disclosed
WO-2012030939-A1 ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT ARENA PHARMACEUTICALS, INC. (US) 2012-03-08 WO disclosed