Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 5/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16119960 | 0.87 | PRMT1 (0.46) | PRMT5WDR77HTR1DPRMT1CARM1 | |
| SCHEMBL16120044 | 0.77 | JAK2 (0.40) | — | |
| SCHEMBL16120007 | 0.76 | PRMT5 (0.41) | PRMT5WDR77HTR1DPRMT1GSK3B | |
| SCHEMBL14486911 | 0.72 | JAK2 (0.50) | PRMT5WDR77HTR1DGSK3BBACE1 | |
| SCHEMBL16119983 | 0.70 | KDM4E (0.37) | HTR1DPRMT1CARM1PRMT6PRMT8 | |
| SCHEMBL14486913 | 0.70 | PRMT5 (0.46) | PRMT5WDR77HTR1DGSK3BEPHX2 | |
| SCHEMBL17469510 | 0.70 | PRMT1 (0.49) | PRMT5WDR77PRMT1CARM1PRMT6 | |
| SCHEMBL16187095 | 0.69 | PRMT1 (0.41) | HTR1DPRMT1CARM1BCHEBACE1 | |
| SCHEMBL29342992 | 0.69 | HTR1D (0.45) | PRMT5WDR77HTR1DGSK3BBACE1 | |
| SCHEMBL29347617 | 0.69 | HTR1D (0.45) | PRMT5WDR77HTR1DGSK3BBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014153235-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |